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KMID : 1143920230270010107
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Annals of Hepato-Biliary-Pancreatic Surgery
2023 Volume.27 No. 1 p.107 ~ p.113
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Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: Three case reports and a literature review
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Sung Min-Kyu
Lee Woo-Hyung
Hong Sa-Rang
Park Ye-Jong
Kwak Bong-Jun
Song Ki-Byung
Lee Jae-Hoon
Hwang Dae-Wook
Kim Song-Cheol
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Abstract
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Mixed adenoneuroendocrine carcinoma is defined as a tumor with a mixture of adenocarcinoma components and neuroendocrine neoplasm components. Each of these two components of mixed adenoneuroendocrine carcinoma accounts for at least 30% of all tumors. Mixed adenoneuroendocrine carcinoma might be located in the ampulla of Vater, a very rare location compared to other organs. Thus, its treatment and prognosis plans have not been established yet. We report three cases of mixed adenoneuroendocrine carcinoma occurring in the ampulla of Vater. Each patient had a different clinical course. In general, difficulty in preoperative diagnosis, risk of early recurrence, and poor disease course were main hallmarks of mixed adenoneuroendocrine carcinoma arising from the ampulla of Vater. However, one patient in this case report survived although she did not receive adjuvant chemotherapy due to her old age. Therefore, it is important to establish a careful treatment strategy for mixed adenoneuroendocrine carcinoma arising from the ampulla of Vater.
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KEYWORD
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Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: Three case reports and a literature review
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